Comparison of Hepatoprotective Effect of two Varieties of Garlic (allium Sativum Var Chinese Exotic and Allium Sativum Var Lehsun Gulabi)on Acetaminophen Induced Acute Hepatitis in Male Albino Rats

Abstract

Objective: To determine and compare the hepatoprotective effect of ethanolic extracts of two
varieties of Allium sativum on acetaminophen induced hepatotoxicity in male albino rats.

Methods: This study was carried out on 120 male albino rats. A single intraperitoneal dose of
acetaminophen 750mg/kg was used to induce hepatotoxicity. The rats were randomly divided into
four groups of thirty each. Group A was given normal saline (control); group B was administered
hepatotoxic dose of acetaminophen(negative control); group C was pretreated with Allium
sativumVar Chinese exotic extract for 7 days before receiving hepatotoxic dose of
acetaminophen (Experimental 1); and group D was pretreated with Allium sativum Var Lehsun
Gulabi extract for 7 days before receiving hepatoprotective dose of acetaminophen
(Experimental 2). Serum ALT, AST and ALP levels in each group were measured from terminal
blood sampling done 24 hours after acetaminophen administration.

Results: The ethanolic extract of Allium sativum Varlehsungulabi showed highly significantly
(p=0.000) greater reduction in serum ALT and AST as compared to the effect of ethanolic extract
of Allium sativumVar Chinese exotic, but there was non significant (p=0.526) difference in serum
levels of ALPbetween the two varieties of garlic.
Conclusions: On comparison, Allium sativumvar Lehsun Gulabi has better hepatoprotective
potential as compared to Allium sativumvar Chinese exotic.