Hepatoprotective and Antioxidative Effectso of Allium Sativum Var Chinese Exoticon in Acetaminophen Induced Acute HepatitisiIn Male Albino Rats

Abstract

Objective: To determine the hepatoprotective and antioxidative effects of ethanolicextract of
Allium sativumvar Chinese exotic on acetaminophen induced hepatotoxicity in male albino rats.
Methods: This study was carried out on 90 male albino rats. A single intraperitoneal dose of
acetaminophen 750mg/kg was used to induce oxidative stress and hepatotoxicity. The rats were
randomly divided into three groups of thirty each. Group A was given normal saline (negative
control); group B was administered hepatotoxic dose of acetaminophen(positive control); group
C (experimental) was pretreated with Allium sativum Var Chinese exotic extract for 7 days before
receiving hepatotoxic dose of acetaminophen (Experimental). Serum ALT, AST, ALP, total
proteins, albumin and glutathione peroxidase levels in each group were estimated from terminal
blood sampling done 24 hours after acetaminophen administration under ether anesthesia.
Results: Allium sativumvarChinese exotic manifested hepatoprotective and antioxidative
effects by producing highly significant (p=0.000) reduction in serum ALT and AST, but no
significant (p=0.335) reduction in serum ALP levels. This garlic extract also produced highly
significant (p=0.000) increase in serum albumin and significant increase in serum total proteins
(p=0.027) and glutathione peroxidase (p=0.025) levels.
Conclusions: Allium sativumvar Chinese exotic has potent hepatoprotective and antioxidative
potential