Effect of Moringa Oleifera Leaves Extract on Bisphenol-A Induced Changes in Venous Drainage of the Liver of Albino Rats

Abstract

Objectives: To observe the effects of Ethanolic extract of Moringa Oleifera leaves on Bisphenol –A (BPA) induced changes in diameter of central vein and venous drainage (central vein, portal and sinusoidal) in liver of albinorats.
Methods: This was an experimental study conducted at the animal house of Anatomy Department, PGMI, Lahore. Thirty two albino rats of both sex, weighing 170-200 gms were divided equally into 4 groups as A(control), B, C and D (other groups were experimental). Group A, received corn oil only. Group B, received BPA only 50mg/kg/body weight (wt)., Group C and D received BPA 50mg/kg along with Moringa Oleifera leaves extract (MoLE) 250mg kg/body wt and 500mg kg/body wt respectively. BPAand MoLE was given in single dose through oral route. At the end of seven weeks, rats were dissected, liver was removed and slides were made by using H&E stain. The effect of MoLE on BPA induced venous changes was observed under
light microscope. The statistical analysis of results was done by using SPSS 21. Results: BPAincreased the diameter of central vein and produced vascular congestion in group B, which was then reduced by administration of MoLE in group C and D. The healing effect of MoLE was augumented as dose was increased.
Conclusions: Moringa Oleifera leaves prevented the vascular congestion and dilatation induced by BPA in liver of rats . The preventive effect improved as dose was increased.

How to cite: Zaheer A., Basit A., Jabeen R., Wasim A., Iqbal Z., Shamim R. Effect of Moringa Oleifera Leaves Extract on Bisphenol-Ainduced changes in Venous drainage of the Liver of Albino Rats. Esculapio 2021;17(02).