Early Biochemical Changes in the Development of Nephropathy in Type II Diabetics

Abstract

Objectives: To detect the early biochemical changes showing the development of diabetic nephropathy in type II diabetics and to recommend some measures to slow down these changes.
Materials and Methods: It was cross-sectional analytical study and was conducted through nonprobability convenient sampling. It comprised of 50 recently diagnosed (within 2 years) patients of type II diabetes mellitus and 50 healthy subjects. Alcoholics, pregnant ladies and individuals having serious infection or disease or having neoplasia were not included in the study. Random blood glucose, blood urea, serum creatinine, urinary albumin and urinary creatinine were estimated and albumin to creatinine ratio (ACR) mg/g was calculated.
Results: Mean values of random plasma glucose level, serum creatinine, urine albumin, urine creatinine and ACR in diabetic group when compared with those of healthy group showed significant P values (≤0.05).
Conclusion: In our setup due to a lack of regular health care type II DM is coincidently diagnosed and it is very difficult to assess the exact duration of the disease and type II diabetics develop nephropathy due to continuous high plasma glucose levels.