Insulin Resistance Syndrome in Type - 2 Diabetes Mellitus Patients

Abstract

Objective: To find out the presence or absence of insulin resistance syndrome (IRS) in type-2
diabetes mellitus patients.
Material & Methods: The study included 55 T2DM patients (34 male & 21 female), who were
already taking oral anti diabetic drugs for the last 3 – 5 years. Obesity or weight gain in T2DM
patients aggravates metabolic disturbances along with increased insulin resistance. The five
variables in T2DM patients were studied as per recommendations of the United States National
Cholesterol Education Program Adult Treatment Panel-III (ATP-III), to find out the presence or
absence of insulin resistance syndrome (IRS) in T2DM patients. The T2DM patients who had
shown the presence of three or more variables out of five z were considered to have IRS.
Results: 32 (58.18%) T2DM patients (20 male & 12 female) had IRS. The T2DM patients with IRS
had significant (p<0.001) increase in mean blood glucose levels, waist circumference, triglyceride
levels and in systolic and diastolic blood pressure. The mean HDL Cholesterol was significantly
(p<0.001) decreased in T2DM patients with IRS as compared to T2DM patients without IRS.
Conclusion: An increase in waist circumference in T2DM patients will increase the prevalence
of insulin resistance syndrome.