Can Vascular Pathology In Cerebral And Coronary Fields Predict Peripheral Artery Disease In A Cohort Of Diabetic Patients?

Abstract

Background: Diabetes mellitus, a metabolic disorder of absolute or relative insulin deficiency, is
characterized by micro and macro-vascular complications. This process of vascular pathology proceeds at
a uniform rate throughout the body. Eventually it may be manifested as atherosclerotic changes in
cerebral, coronary and peripheral arteries Variables like central adiposity, altered metabolism, elevated
blood pressure, proteinuria causes resistance.
Methods: A retrospective cross-sectional study was carried out on 4482 diabetic patients attending the
“Diabetes Management Center” Services Hospital, Lahore. Known determinates of past vascular disease
PVD were assessed. An artery disease index was formulated by the presence or absence of lower limb
pulses.
Results: Past history of CVAwas significantly associated with PVD with a p-value of 0.002. Similarly past
history of M1 (p=0.000), hypertension (p=0.000), proteinuria (p=0.000) were all significantly present in
patients with PVD. There was lack of association between cigarette smoking (p= 0.463) and PVD.
Conclusion: Past history of CVA and MI, Hypertension and Protienuria are all significantly present in
Diabetic patients with Peripheral Vascular disease