Role of H.Pylori Eradication Therapy in Alleviation of Symptoms In H. Pylori Positive Non-ulcer Dyspepsia Patients

Abstract

Abstract: To establish the role of anti H. pylori eradication therapy in alleviation of symptoms in
H. pylori positive non-ulcer dyspepsia (NUD) patients.
Material & Methods: This clinical trial was carried out in the Medical unit II and Medical Special
unit of the Services Hospital, Lahore during the period from 2003 to 2004.100 patients with the
symptoms of dyspepsia without having evidence of peptic ulcer on upper GI endoscopy were
included in the study. Out of these 100 patients 33 were found H. pylori negative on first
endoscopy & histopathology, whereas, the remaining number of 67 was completed by
confirmation of H. pylori eradication in initially positive cases. Post treatment six weeks follow up
was performed to confirm outcome.
Results: The H. pylori eradication therapy did not show statistically significant improvement in
symptoms of NUD patients.
Conclusion: Routine H. pylori eradication has little role in the alleviation of symptoms in patients
with NUD.