Lipoprotein Abnormalities And Body Mass Index Differences In Type 2 Diabetic Postmenopausal Women In Tertiary Care Hospitals Of Peshawar

Abstract

Objective: To detect serum lipoprotein abnormalities and Body Mass Index differences in type
2 diabetic post menopausal women compared to controls
Material & Methods: This case control studywas conducted at Tertiary care hospitals of
Peshawar, that is Hayatabad Medical Complex, Khyber Teaching Hospital, and Lady Reading
Hospital over a period of two years i.e., from July 2005 to July 2008.One hundred and fifty
diagnosed diabetes type 2 post menopausal females compared with fifty non diabetic post
menopausal healthy controls were included. Determination of glucose, total cholesterol, high
density lipoprotein cholesterol were assessed by enzymatic lab technique (Elitech) using micro
lab 200 (Merck), and low density lipoprotein cholesterol was determined by Friedewald formula.
Results: The results indicated highly significant difference between the biochemical indices of
cases and controls which included elevated levels of LDL-C (p=0. 001), reduced levels of HDL-C
(p=0.001) and triglycerides (TG) above the target levels (p=.000). Body Mass Index showed
significant change in diabetic postmenopausal females as compared to controls. (p<0.015).
Conclusion: Dyslipidemias in post menopausal diabetic females are more prevalent.
Lipoprotein abnormalities are a risk factor for cardiovascular diseases which becomes more
prevalent with the loss of estrogens and the decrease in High density lipoprotein (HDL)
cholesterol levels that occurs concurrently with menopause.