Comparative Analysis of Oxytocin Versus Vaginal Prostaglandin in Induction of Labour in Pre Labour Rupture of Membrane

Abstract

Objective: To determine the mean time from induction to delivery after spontaneous pre-labour rupture of
membrane using I/V oxytocin versus vaginal prostaglandin E2.
Method: The study was randomized clinical trial carried out in gynae unit IV Sheikh Zayyed Hospital
Lahore. Over a period of six months from July 2019 to Dec 2019. A total of 100 pregnant ladies with age range
18 years to 40 years and having gestational age > 37 weeks were included. Pregnant women with twin
pregnancy, and with placenta previa or abruptio placenta and females with any known fetal or maternal risk
assessed on clinical examination and those who have congenital abnormality at the time of presentation were
also excluded from study. Later on patients were divided randomly into two groups using random number
table. Group A (50 patients) patients was given intravenous oxytocin 1 m unit/min in infusion while group B
(50 patients) patients was given 3mg prostaglandin E2 vaginaly. Effect modifier like BMI, hypertension and
pregnancy induced hypertension will also be recorded. Patients were observed for the time of induction of
delivery as per operational definition. Data was entered on computer software SPSS version 21 Independent
t-test was applied to compare the mean time between both groups.
Results: There was significant difference between two groups for mean duration of labor as mean duration of
induction of labor was 3.92±1.74 in the oxytocin group while 9.38±3.71 in prostaglandin group with a p-
value of 0.001.
Conclusion: Oxytocin is effective in terms of reduction in time of induction of labor to delivery as compared
to prostaglandin E2.

How to cite: Danish S, Najeeb W, Javed A, Shahid R, Sharif S, Matloob M. Comparative Analysis of Oxytocin Versus
Vaginal Prostaglandin in Induction of Labour in Pre Labour Rupture of Membrane. Esculapio - JSIMS 2022;18(02):118-121
DOI: https://doi.org/10.51273/esc22.251823