Efficacy of Tranexamic acid in Menorrhagia in comparison to norethisteron

Abstract

Objective:To compare the efficacy of tranexamic acid with norethisterone in the management of
menorrhagia.
Material & Methods: Total 66 patients were included in this study (33 patients randomly
allocated to Group Aand B).
Results: In group Aand group B mean age was 33.12±4.98 and 31.42±5.47 years respectively.
After management, number of towels used/day were reduced in group A and B and were
3.21±0.65, 2.85±0.62, 2.33±0.54, 2.21±0.60 and 3.30±0.88, 3.15±0.87, 2.94±1.03, 2.85±1.06 at
one, two, three and six months follow-up respectively with significant difference between two
groups ( p=0.002). Passage of blood clots in group Aand B at one, two, three and six months were
reduced in patients 19 (57.5%), 19 (57.5%), 20 ( 60.6%), 23 (69.6%) and 10 (30.4%), 13
(39.4%), 12 (36.4%), 12 (36.4%) respectively (p=0.0035). Haemoglobin level in group A was
9.633±0.946 g/dl at six months while in group B it was 9.385±1.061 g/dl with insignificant result in
both groups ( p=0.159).
Conclusion: Tranexamic acid is more safe, effective and tolerable treatment than norethisterone for patients with ovulatory menorrhagia with avoidance of possibly unnecessary surgery.