The Jak2 V617 Mutation Triggers Erythropoiesis And Patients Presented With Good Hemoglobin Level In Idiopathic Myelofibrosis (IMF)

Abstract

Objective: To document the impact of JAK2 mutation on haemoglobin(Hb) level in patients with
IMF.
Methods: Thirty five patients were studied in which 19 patientswere JAK2 positive and 16
patients were JAK2 negative. Sample collection technique was purposive non-probability
sampling. Variations were observed among the studied JAK2 positive and JAK2 negative
patients regarding haemoglobin level.
Results: The total haemoglobin level was compared in between JAK2 positive and negative
patients. In JAK2 positive and negative patients mean haemoglobinlevel was 10.6g/dl and 8.6g/dl
respectively.
Conclusion: Due to the better haemoglobin level, patients with JAK2 mutation have less
transfusion requirements and partially protect against severe anemiaas compared to patients
with no mutation