Morpholoical Effects of Ribavirin on Adult Ovary of Albino Rat

Abstract

Objective: To evaluate the morphological effects of ribavirin on adult ovary of albino rats.
Material and Methods: This experimental study was conducted in the Department of Anatomy,
Shaikh Zayed Postgraduate Medical Institute, Lahore in collaboration with Department of
Zoology, Quaid-e-Azam Campus, University of Punjab. Doses of 20.200mg/kg of ribavirin were
give to albino rats orally for five consecutive days at intervalsof 24 hrs. The ovaries were
processed for histopathological analysis on day 14 after this last exposure. the gross parameters
studies were body weight, paired ovarian wight, relative tissue weight index (RTWI). Data was
analysed by ANOVA and Turkey’s test for statistically significant difference.
Results: There was decrease in body wight of experimental groups compared with control at
higher dose-levels i.e 100 and 200mg/kg. When paired ovarian weight were compared among
groups the overall difference was significant. Post hoc analysis revealed that low dose group had
significantly low ovarian weight as compared to control. when RTWI was compared among
groups the overall difference was significant. Post hoc analysis revealed that low dose group i.e.
20mg/kg had significantly low RTWI as compared to control.
Conclusion: Ribavirin administration in adult female rat showed significant harmful effects on
ovary, and these gonadotoxic effects of ribavirin may cause infertility in females during
reproductive period