Comparison Of Serum Anti-mutated Citrullinated Vimentin Antibody With Anti-cyclic Citrullinated Peptide Antibody As A Diagnostic Marker In Local Pakistani Rheumatoid Arthritis Patients

Abstract

Objective: To compare the diagnostic value of antibodies against mutated citrullinated vimentin
(anti-MCV) and antibodies to cyclic citrullinated peptides (anti-CCP) in patients with rheumatoid
arthritis.
Material and Methods: A total of 88 subjects were included in the study, comprising of 58
known patients of rheumatoid arthritis (fulfilling the American College of Rheumatology
Criteria).Thirty age and sex matched normal healthy volunteers were included as controls in the
study. Sera of all study subjects were tested by ELISA for presence of anti-MCV and anti-CCP
antibodies.
Results: The sensitivity and specificity of serum anti CCP antibodies for RA was calculated to be
58.6% and 86.7% respectively. The sensitivity and specificity of serum anti MCV antibodies for RA
was calculated to be 34.5% and 70.6% respectively at the manufacturer's cutoff value of 25U/L.
Conclusion: Anti-cyclic citrullinated peptide antibodies have higher sensitivity and specificity
for the diagnosis of RA as compared to anti-mutated citrullinated vimentin antibodies