Association of Helicobacter Pylori infection with Liver cirrhosis among Patients Presenting in a Tertiary Care Hospital of Lahore, Pakistan
DOI:
https://doi.org/10.51273/esc23.251319417Keywords:
Helicobacter Pylori Infection, Liver Cirrhosis, Association, Stool antigenAbstract
Objective: To determine the association of H. pylori infection with liver cirrhosis among patients presenting in a tertiary care hospital of Lahore, Pakistan.
Material and Methods: This case control study was conducted at Medicine wards, Mayo Hospital, Lahore for six months.130 patients including 65 cases of liver cirrhosis (ultrasonography proven) and 65 healthy volunteers as controls were taken through non-probability consecutive sampling technique. A stool sample for Helicobacter Pylori antigen detection was taken from both cases and controls following standard sterile collection procedure. Samples were then submitted to the pathology laboratory. H. pylori antigen results were noted in a predesigned proforma. Data was analyzed using SPSS 24.0.Then the association of helicobacter pylori with liver cirrhosis was recorded by calculating taking odds ratio and taking it >1 as statistically significant.
Results: The minimum age recorded in our study was 20 years and maximum age noted was 70 years. Mean age + standard deviation were 44.32 ± 13.72 years. We had 66 (50.8%) male and 64(49.2%) female patients. Out of 65 cases, helicobacter pylori infection was found in 48(73.85%) while in 65 controls, helicobacter pylori infection was found in 29(44.62%) patients. Presence of helicobacter pylori was significantly associated with liver cirrhosis as odds ratio=3.51 and p-value = 0.001.
Conclusion: Helicobacter pylori infection was significantly associated with liver cirrhosis. Hence early diagnosis and treatment may decrease the complications.
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