Serum Anti- Mcv Antibodyand Its Correlation With Disease Activity In Local Pakistani Rheumatoid Arthritis Patients

Abstract

Objective: To investigate the correlation of anti-mutated citrullinated vimentin (anti-MCV) titers
with clinical manifestations and disease activity in a cohort of patients with established diagnosis
of rheumatoid arthritis.
Material and Methods: A total of 58 patients attending the Rheumatology outpatient
department of Fatima Memorial Hospital, Lahore were recruited in the study. Data of disease
related parameters such as disease duration, medications, degree of pain (visual analog scale,
VAS), disease activity score 28 (DAS 28), and health assessment questionnaire (HAQ) were
recorded. Laboratory workup included erythrocyte sedimentation rate (ESR>20mm/hr
considered positive), rheumatoid factor (determined by ELISA technique), anti-CCP antibody
(ELISAImmco Diagnostics, USA) and anti-MCV antibody (Cusabio Biotech Co., Ltd, China).
Results: The anti-MCV antibody levels did correlate with the number of tender joints (p=0.001),
swollen joints (p=0.001), VAS (p=0.330), ESR (p=0.001), DAS28 scores (p=0.001). However, no
significant correlation of aMCV titers with HAQ scores (p=0.090) and anti-CCP titers (p=0.685)
and serum RF titers (p=0.621) was observed.
Conclusion: In Significant correlation was noticed between the serum anti-MCV antibody titers
and DAS-28 and other disease activity parameters besides HAQ-DI and anti-CCPand RF titers