Effect of N-Acetylcysteine Therapy on Mortality Rate in Patients of Acute Aluminium Phosphide Poisoning

Abstract

Objective: To determine the effect of N-acetylcysteine therapy on mortality rate in patients of acute aluminium phosphide poisoning.
Method: This Randomized Controlled Trial was conducted in the Department of Medicine, , King Edward Medical University/ Mayo Hospital, Lahore from January 2018 to March 2019. Ninety-six patients with acute aluminium phosphide poisoning were selected via simple random sampling technique. The patients were divided into two groups, group A received supportive management and group B received N-acetylcysteine therapy along with supportive care. The patients were followed up to the primary end points of the study i.e. either discharge from hospital after recovery or death. Relevant information was recorded on a pre-designed proforma. Data analysis was done using SPSS Version 23.0.
Results: Out of a total of 96 patients, 50(52.1 %) were males and 46(47.9 %) were females. Mean age of the patients was 27.5± 9.8 years. In Group A (supportive therapy), 29(60.4%) patients died while 19(39.6%) were discharged after recovery. In Group B (N-acetylcysteine + supportive therapy), 17(35.4%) patients died while 31(64.6%) were discharged after recovery. N-acetylcysteine therapy significantly reduced mortality in patients with acute aluminium phosphide poisoning (p=0.024)
Conclusion: N-acetylcysteine in combination with supportive therapy significantly reduced mortality rate in patients with acute aluminum phosphide poisoning compared to supportive therapy alone.

How to cite: Ashraf S, Nazar T, Aziz B, Farooq H, Nazar N. Effect of N-acetylcysteine Therapy on Mortality Rate in Patients of
Acute Aluminium Phosphide Poisoning. Esculapio - JSIMS 2022;18(03):324-328