Intravenous Lidocaine Versus Normal Saline in Patients Undergoing Laparoscopic Surgery; A Comparison of Mean Consumption of Postoperative Analgesia Requirement

Abstract

Objective: To compare the mean postoperative opioid consumption in patients with and without
use of perioperative intravenous lidocaine undergoing laparoscopic surgery
This Randomized controlled trial was conducted in Department of Anesthesiology,Methods:
Lahore General Hospital. A total of 100 cases undergoing laparoscopic surgery were included
through Non-probability, Purposive sampling.Informed consent and demographic information
were obtained. Patients were randomly divided in two equal groups by using lottery method. In
group A, patients were given intravenous 1.5mg/kg bolus of lidocaine followed by 2mg/kg/hr
infusion of lidocaine till end of procedure and in group B, normal saline was given in same volume
to the patients. All surgeries were performed by the same surgical team and most of the
procedures were completed within 60 mins. The infusion was continued for one hour to those
patients whose surgery was completed earlier than an hour. Postoperative opioid consumption
was noted till 24 hours. All the information was recorded on a proforma. Data was entered and
analyzed through SPSS 16. Both groups were compared for mean consumption of postoperative
opioid by using t-test taking P-value<0.05 as significant.
Results: In this study, the mean age of patients was 49.34±10.30 years. Out of 100 patients,
there were 20 (20%) male and 80 (80%) females.In lidocaine group, the total mean opioid
consumption during 24 hours after surgery was 81.80±17.01mg whereas with Normal Saline was
89.35±17.74mg. There was significant difference found between both groups (p-value=0.032) for
total opioid consumption where patients in lidocaine group has less consumption of opioids.
Conclusion: It was concluded from results of the study that total opioid consumption is less
whenlidocaine infusion was used during surgery