Comparison of 2% Vaginal Clindamycin with Oral Metronidazole for Treatment of Bacterial Vaginosis At Services Hospital Lahore

Abstract

Objective: To compare the efficacy and safety of local application of 2% vaginal clindamycin
with oral metranidazole for treatment of bacterial vaginosis.
Methods: Two hundred married women were included in the study in which bacterial vaginosis
was diagnosed by standard criteria. Patients were randomized to two group with 100 patients in
each group. One group (A) were treated with oral metronidazole, 400mg, three time daily for
seven days, while group (B) patients were treated with intravaginal clindamycin 2% cream for
seven days. The symptoatic response of the both groups was checked by follow up after one
week, 3 month and then 6 months after completion of treatment.
Results: In group A14 (14%) patients were free of symptoms with in seven days 68 (68%)
patients after seven days and 18 patients (18%) had no alleviation, while in group B 20 (20%)
patients were free of symptoms within seven days, 74 (74%) patients after seven days and 6(6%)
patients had no alleviation of problem. In group A 10 patients (10%) had vomiting and diarrhea, 14
(14%) patients had abdominal pain. In group B, 2 (2%) patient had abdominal pain and 10 (10%)
patients had local irritation and swelling. There were 18 (18%) patients who had failure of
response of treatment in group A and 6 (6%) patients in group B had failure. In group A 16 (16%)
patients had recurrence after three months and 12 (12%) patients in group B.
Conclusion: It is concluded from our study that 2% intravaginal clindamycin; is better than oral
metronidazole in the treatment of bacterial vaginosis in term of improvement / cure rate, side
effect, failure rate and recurrence rate