Correlation of Vitamin D and Calcium Levels and their Biochemical Importance in Diabetic Patients

Tayyaba Yasin; Mariyam Khan; Hafsa Iqbal; Hasnain Azam; Shazia Sukhera; Hafiza Amna Arif

doi:10.51273/esc23.251319410

Authors

Tayyaba Yasin The University of Lahore
Mariyam Khan The University of Lahore-Pakistan
Hafsa Iqbal The Islamia University Of Bahawalpur-Pakistan
Hasnain Azam The University of Lahore-Pakistan
Shazia Sukhera The University of Lahore-Pakistan
Hafiza Amna Arif The University of Lahore-Pakistan

DOI:

https://doi.org/10.51273/esc23.251319410

Keywords:

Diabetes, vitamin D, Serum Calcium, Calcium, Uric acid, correlation, Biomarkers

Abstract

Objective: The aim of study is to determine the correlation between vitamin D and calcium levels and their biochemical importance in diabetic patients.
Materials and Methods: A cross-sectional study compared vitamin D and calcium levels in 50 diabetic patients recruited from the University of Lahore Hospital. Selection criteria were age, sex, diabetes duration, and current and previous medication use. Each person who took part in the study gave their informed permission. We collected venous blood samples were examined for vitamin D, calcium levels and urine for uric acid level in accordance with standard laboratory techniques and commercially-available kits. SPSS
26.0 was used for the statistical analysis. Mention study design
Results: Diabetic patients exhibited significantly lower levels of both vitamin D (20.4±4.8) and calcium (9.2± 0.9) compared to the healthy control group (p<0.001). There was a significant positive correlation between vitamin D and calcium levels in diabetic patients (r = 0.67, p < 0.001). Diabetic patients also had higher uric acid levels (6.1±1.2) than healthy controls (p<0.05).
Conclusion: The conclusion shows that vitamin D and calcium levels are positively correlated in diabetic patients. There may be a connection between uric acid metabolism and the pathogenesis of diabetes, as evidenced by the higher uric acid levels in diabetic patients.

Author Biographies

Mariyam Khan, The University of Lahore-Pakistan

Doctor

Hafsa Iqbal, The Islamia University Of Bahawalpur-Pakistan

Student

Hasnain Azam, The University of Lahore-Pakistan

Student

Shazia Sukhera, The University of Lahore-Pakistan

Doctor

Hafiza Amna Arif, The University of Lahore-Pakistan

Student

References

Shahzad F, Ishaque A, Saleem F. Prediabetes in adolescents-an emerging epidemic–a cross-sectional survey of medical students at a public university, Quetta, Pakistan. J Pak Med Assoc. 2021;71(5):1438-41.

Punthakee Z, Goldenberg R, Katz P. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Canadian journal of diabetes. 2018;42:S10-S5.

Lucato P, Solmi M, Maggi S, Bertocco A, Bano G, Trevisan C, et al. Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis. Maturitas. 2017;100:8-15.

Islam F, Khadija JF, Islam R, Shohag S, Mitra S, Alghamdi S, et al. Investigating polyphenol nanoformulations for therapeutic targets against diabetes mellitus. Evidence-Based Complementary and Alternative Medicine. 2022;2022.

Malik R, Farooq R, Mehta P, Ishaq S, Din I, Shah P, et al. Association of Vitamin D receptor gene polymorphism in adults with type 2 diabetes in the Kashmir Valley. Canadian journal of diabetes. 2018;42(3):251-6.

Makoui MH, Imani D, Motallebnezhad M, Azimi M, Razi B. Vitamin D receptor gene polymorphism and susceptibility to asthma: meta-analysis based on 17 case-control studies. Annals of Allergy, Asthma & Immunology. 2020;124(1):57-69.

Elmoselhi AB, Seif Allah M, Bouzid A, Ibrahim Z, Venkatachalam T, Siddiqui R, et al. Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients. Plos one. 2023;18(3):e0283608.

Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. The American journal of medicine. 2002;112(8):659-62.

Looker AC, Dawson-Hughes B, Calvo M, Gunter E, Sahyoun N. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30(5):771-7.

Heshmat R, Mohammad K, Majdzadeh S, Forouzanfar M, Bahrami A, Omrani GR, et al. Vitamin D deficiency in Iran: A multi-center study among different urban areas. Iranian Journal of Public Health. 2008:72-8.

Li L, Shang F, Zhu Y, Sun Y, Sudi RS. Modulation of VDR and cell cycle-related proteins by vitamin D in normal pancreatic cells and poorly differentiated metastatic pancreatic cancer cells. Nutrition and cancer. 2019;71(5):818-24.

Al Safar H, Chehadeh SEH, Abdel-Wareth L, Haq A, Jelinek HF, ElGhazali G, et al. Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus. J Steroid Biochem Mol Biol. 2018;175:119-24.

Mehta S, Parminder N, Agrawal BK, Singh RP. Vitamin D with Calcium Supplementation Managing Glycemic Control with HbA1c and Improve Quality of Life in Patients with Diabetes. Turkish Journal of Pharmaceutical Sciences. 2022;19(2):161.

Zhu J, Xun P, Bae JC, Kim J, Kim D, Yang K, et al. Circulating calcium levels and the risk of type 2 diabetes: a systematic review and meta-analysis. British Journal of Nutrition. 2019;122(4):376-87.

Rooney MR, Pankow JS, Sibley SD, Selvin E, Reis JP, Michos ED, et al. Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. The American journal of clinical nutrition. 2016;104(4):1023-9.

Van Hove I, De Groef L, Boeckx B, Modave E, Hu T-T, Beets K, et al. Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy. Diabetologia. 2020;63:2235-48.

Bayani MA, Akbari R, Banasaz B, Saeedi F. Status of Vitamin-D in diabetic patients. Caspian journal of internal medicine. 2014;5(1):40.

Verdoia M, Nardin M, Gioscia R, Saghir Afifeh AM, Viglione F, Negro F, et al. Association between vitamin D deficiency and serum Homocysteine levels and its relationship with coronary artery disease. Journal of thrombosis and thrombolysis. 2021;52(2):523-31.

Gnanaprakash V, Bodhini D, Kanthimathi S, Ginivenisha K, Shanthirani CS, Anjana RM, et al. Association of Vitamin D receptor (TaqI, BsmI, and FokI) polymorphisms with prediabetes and Type 2 diabetes in Asian Indians. Journal of Diabetology. 2019;10(1):29.

Arnaudova M, Totomirova T. IDF21-0313 Effect of moderate doses vitamin D on polyneuropathy in type 2 diabetes patients. Diabetes Research and Clinical Practice. 2022;186.

Hussein ET. The role of Calcium and Vitamin D In Type II Diabetes Mellitus. Eurasian Scientific Herald. 2023;21:91-102.

Hashim Z, Qasim Q, ALabbood M. The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes. Archives of Razi Institute. 2022;77(5):1593-600.

Nigah SL, Jagota G, Singh S, Goyal G. Evaluation of vitamin-D, calcium, and phosphorus levels among diabetes mellitus type 2 in malwa belt of Punjab. Medical Journal of Dr DY Patil University. 2022;15(2):222-8.

Ji P, Zhu J, Feng J, Li H, Yu Q, Qin H, et al. Serum uric acid levels and diabetic kidney disease in patients with type 2 diabetes mellitus: A dose-response meta-analysis. Primary care diabetes. 2022;16(3):457-65.

Khudayar M, Nadeem A, Lodi MN, Rehman K, Jawaid SI, Mehboob A, et al. The association between deficiency of vitamin D and diabetes mellitus type 2 (DMT2). Cureus. 2022;14(2).