A Comparison of Fine Needle Aspiration Cytology (FNAC) with Tru-cut Biopsy in Breast Lump Patients Taking Histopathology as Gold Standard
DOI:
https://doi.org/10.51273/esc23.251319317Keywords:
breast lump, FNAC, TRU CUTAbstract
Objective: To compare sensitivity and specificity of FNAC with Tru-cut biopsy diagnosis of breast lump patients.
Material and Methods: It was a cross sectional study conducted at surgical department of Gulab Devi Teaching Hospital Lahore from January 2022 to December 2022. Atotal of 122 patients presented in surgical OPD with complaints of breast lump of size between 2cm to 4 cm were included in the study with their consent. All these patients underwent FNAC, true cut biopsy and excisional biopsy. Sensitivity and specificity of both FNAC and true cut were calculated.
Results: Mean age of patients included in this study was 35.4 ± 14.6 years. The sensitivity and specificity of FNAC in benign breast diseases was 98.2% and 74.2% respectively while in malignant diseases it was 72.7% and 98.8% respectively (p-value 0.00). The sensitivity and specificity of Tru-cut in breast diseases was 100% and 97.1% respectively while in malignant diseases it was 97% and 98.2% respectively (p-value 0.00).
Conclusion: Breast lump is more common in females as compared to males. Breast carcinoma is more common in old females and benign breast diseases is common among young females. Tru-cut biopsy is better than FNAC in diagnosis of both benign and malignant lesions of breast lumps.
References
Ajitha M, Babu V, Singh A. Comparative study of fine needle aspiration cytology, trucut biopsy and final histopathological examination in breast lumps. Int J Biomed Res. 2017;8(3):34-5.
Bukhari MH, Arshad M, Jamal S, Niazi S, Bashir S, Bakhshi IM. Use of fine-needle aspiration in the evaluation of breast lumps. Pathology research international. 2011;2011.
Jan Y, Hussain S, Waqas SM, Din A, Khan A. Comparison of fine needle aspiration cytology (FNAC) and Trucut biopsy in evaluation of suspicious palpable breast lesions. Rawal Med J. 2016 Apr 1;41:205-8.
Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F. Male breast cancer: a disease distinct from female breast cancer. Breast cancer research and treatment. 2019 Jan 15;173:37-48.
Pangotra DM, Aithmia DR, Atri DS. Cytomorphological spectrum of various breast lumps using FNAC as diagnostic modality. Int J Clin Diagn Pathol. 2022;5(3):05-11.
Abbas AK. The incidence of malignancy in breast lumps in females: A prospective population study. Pakistan Journal of Medical & Health Sciences. 2021 Jul;15(7):2371-3.
Zaheer S, Shah N, Maqbool SA, Soomro NM. Estimates of past and future time trends in age-specific breast cancer incidence among women in Karachi, Pakistan: 2004–2025. BMC public health. 2019 Dec;19:1-9.
Sripan P, Sriplung H, Pongnikorn D, Virani S, Bilheem S, Chaisaengkhaum U, Maneesai P, Waisri N, Hanpragopsuk C, Tansiri P, Khamsan V. Trends in female breast cancer by age group in the Chiang Mai population. Asian Pacific Journal of Cancer Prevention: APJCP. 2017;18(5):1411.
Ogbuanya AU, Anyanwu SN, Iyare FE, Nwigwe CG. Fine Needle Aspiration Cytology for Diagnosis of Benign Breast Disease in A Resource-Limited Setting. Orient Journal of Medicine. 2020 Jun 5;32(1-2):28-37.
Kumar KS, Anbalagan P, Udhayasankar V. Clinical study of benign breast diseases. Evolution Med. Dent. Sci. 2017 Jan 5;6(02):132-5.
Mohanty SS. Diagnostic accuracy of fine needle aspiration cytology (FNAC) in detecting breast malignancy with the clinical location of lumps. The Breast Journal. 2020 Dec;26(12):2395-9.
Wang M, He X, Chang Y, Sun G, Thabane L. A sensitivity and specificity comparison of fine needle aspiration cytology and core needle biopsy in evaluation of suspicious breast lesions: A systematic review and meta-analysis. The breast. 2017 Feb 1;31:157-66.
Jan Y, Hussain S, Waqas SM, Din A, Khan A. Comparison of fine needle aspiration cytology (FNAC) and Trucut biopsy in evaluation of suspicious palpable breast lesions. Rawal Med J. 2016 Apr 1;41:205-8.
Amarnath N, Kumar SV, Babu CG. Role of Ultrasound and Tru-Cut Biopsy in Breast Lumps: A Contemporary Review. Annals of SBV. 2021 Jul;10(2):43.