Frequency and Management Outcome in Gynecological Malignancies
DOI:
https://doi.org/10.51273/esc23.251319316Keywords:
malignancy, cancer patientsAbstract
Objective: The study was done to find out the frequency of different gynaecological malignancies, histological types and management outcome of these malignancies.
Material and Methods: This study was conducted in unit III of Obtetrics and Gynecology Department, Jinnah Hospital, Lahore. Duration of study was 2 years from January 2018 to December 2019 and sample size was 81. All the cases presented with gynaecological cancer was analysed retrospectively by reviewing record. Complete data was evaluated in term of frequency of malignancies and their percentages.
Results: The most common site of gynaecological malignancy was cervical 35 cases (43.2%) followed by ovarian 30 cases(37%).Uterine wasthe 3rd most common tumour with 13 cases(16%).The vulval and vaginal cancers were found to be lowest with 01 case each (1.2%). There was one case of choriocarcinoma (1.2%).
Conclusion: Cervical cancer was the commonest cancer with squamous cell histological type (80%) followed by ovarian cancer of epithelial origin (73.3%).
References
Pal S, Incidence of Gynecological Cancers, US Pharm. 2014; 39(9):11.
Dalsaniya M, Choksi TS, Shrivastava A, Agnihotri AS. Retrospective and prospective histopathological study of tumors and tumor-like lesions of female genital tract. Int J Med Sci Public Health. 2015;4(11):1602-04.
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA a Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660 [PubMed] [CrossRef] [Google Scholar]
Stelzle D, Tanaka LF, Lee KK, et al. Estimates of the global burden of cervical cancer associated with HIV. Lancet Glob Health 2020; published online Nov 16. DOI:S2214-109X(20)30459-9.
The Economist Intelligence Unit (2009). Breakaway: The global burden of cancer-challenges and opportunities. The Economist Intelligence Unit Limited, pp. 1-73.
Doufekas K, Olaitan A. Clinical epidemiology of epithelial ovarian cancer in the UK. International journal of women’s health. 2014; 6:537.
Dhakal HP, Pradhan M. Histopathological pattern of gynecological cancers. J Nepal Med Assoc. 2009; 48:301-05.
Cervical cancer alarm in Pakistan. Internewsreport (Mevarick Pakitancom). Saturday 13Dec 2014
Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available at: https://gco.iarc.fr/today, (Accessed on: February 02, 2021).
Okeke TC, Onah N, Ikeako LC, Ezenyeaku C.The frequency and pattern of female genital tract malignancies at the universities of Nigeria Teaching Hospital, Enugu, Nigeria. Ann Med Health Sci Res 2013; 3:345-8.
Jeph V, Adreena, Garg PK, Mahabole K. Incidence of different malignancies in female genital tract: study in 504 women in rural population. Int J of Contemporary Med Res. 2017;4(1):284-6.
Tidy J, Seckl M, Hancock BW,on behalf of Royal College of Obstetrics and Gynaecology. Management of Gestational Trophoblastic Diseases. JOG 2021; 128: e1-e27.
Tabassum S, Masood AI, Khakwani M. Pattern of gynecological malignancies in south Punjab Region of Pakistan: An overview of 5 years. Professional Med J 2021; 28(1): 90-5.
Afridi HK, Zahid NA. Frequency of gynecological malignancies in a Tertiary Care Certre in Karachi, Pakistan. Liaqat National J 2021;3(1):3-6.
Okoye CA (2014). Histopathological Pattern of Cervical Cancer in Benin City, Nigeria. The Journal of Medical Investigation Practice 9:147- 150.
Yakasai IA, Ugwa EA, Otubu J (2013). Gynecological malignancies in Aminu Kano Teaching Hospital Kano: A 3-year review. Nigerian Journal of Clinical Practice 16(1):63-66.
D’alo D, Stracci F, Cassetti T, Scheibel M, Pascucci C, La Rosa F. Recent trends in incidence, mortality and survival after cancer of the female breast and reproductive organs. Umbria, Italy: 1978-2005. Eur J Gynaecol Oncol. 2010; 31:174-8
Sumaira Yasmin, Aiman Yasmin, Mohammad Asif. Clinico histological pattern of ovarian tumours in Peshawar region. J Ayub Med Coll 2008; 20(4):11-13.
Manzoor H, Naheed H, Ahmad K, Iftikhar S, Asif M, Shuja J, Sultan N, Ali I, Inayatullah S, Khan YH. Pattern of gynaecological malignancies in south western region of Pakistan: An overview of 12 years. Biomedical reports. 2017 Nov 1; 7(5):487-91.
Liu Z, Zhang TT, Zhao JJ, Qi SF, Du P, Liu DW, Tian QB. The association between overweight, obesity and ovarian cancer: A meta-analysis. Japanese journal of clinical oncology. 2015 Oct 21; 45(12):1107-15.
Medard ML, Ostrowska L. Combined oral contraception and the risk of reproductive organs cancer in women. Ginekol Pol. 2007; 78:637-41.
Stewart BW, Kleihues P. Cancers of female reproductive tract. In;World cancer report. IARC Press, Lyon2003.
Seleye-Fubara D, Uzoigwe SA, Akani CI. Pathology of vaginal cancers in Port Harcourt, Nigeria. A 14-year study. Niger J Clin Pract. 2007; 10:330-4.
Zawislak AA, Price JH, Dobbs SP, McClelland HR, McCluggage WG. The management of vulval intraepithelial neoplasia in Northern Ireland. Int J Gynecol Cancer. 2006; 16:780-5.