Comparison of Hemodynamic Parameters of Propofol and Sevoflurane During Cardiopulmonary Bypass Time in Patients Undergoing Coronary Artery Bypass Graft: A Randomized Control Trial

Abstract

Objective: To compare hemodynamic parameters of propofol and sevoflurane during cardiopulmonary bypass time in patients undergoing coronary artery bypass graft (CABG) surgery to avoid increase in lactate level.
Method: One hundred and twenty-six patients were included. Non probability consecutive sampling was used. Patients were divided in two groups, propofol was given to group 1-P, and sevoflurane to group II-S. Age, clamp-time, bypass-time, mean arterial blood pressure on bypass machine, lactate level (pre-cross clamp lactate level and post-rewarming lactate) and flow-rates on CPB were compared between two groups. SPSS version 24 was used and p value ≤ 0.05 was considered as significant.
Results: The mean pre-cross clamp lactate level, post- rewarming lactate, total noradrenaline dose used, MAP (Mean Arterial Pressure) during CPB, flow-rate, total bypass-time and cross clamp-time of Group-I w a s 1 . 7 9 ± 0 . 5 8 m m o l / L , 4.67±0.98 mmol/L, 0.088±0.04μg/kg, 65.37±2.14 mmHg, 5.23±1.06L/min=(CI×BSA), 109.04± 3.08 minutes and 67.90±2.08minutes , respectively. The mean pre-cross clamp lactate level, post- rewarming lactate, total noradrenaline dose, MAP during CPB, flow-rate, total
bypass-time and cross clamp-time of Group-II was 1.88±0.62 mmol/L, 4.75±0.22 mmol/L, 0.18±0.12μg/kg, 69.69±2.22 mmHg, 4.66±2.29L/min=(CI×BSA), 110.12±2.82minutes and 68.63±2.47minutes , respectively. The differences were statistically insignificant, except total Noradrenaline dose (p=0.000) and MAP during CPB (p=0.000).
Conclusion: Study reveals that hemodynamic stability in both groups remained same but mean arterial pressure was low which required higher flow-rate. Group II showed increase requirement of vasopressors.

How to cite: Farwa KU, Sakina F, Ahmad B, Majeed F, Afzal W, Jahangeer M. Comparison of Hemodynamic Parameters of
Propofol and Sevoflurane During Cardiopulmonary Bypass Time in Patients Undergoing Coronary Artery Bypass Graft: A
Randomized Control Trial. Esculapio - JSIMS 2022;18(03):305-309