Prevention of Fall In White Blood Cell Count by Carica Papaya Leaf Juice In Carboplatin Induced Leucopenia In Mice

Abstract

Objective: To determine the effect of different doses of male and female papaya leaf juice on
prevention of carboplatin induced leucopenia in mice.
Methods: A total of 55 Swiss albino mice were randomly divided into five groups (C,M10, M5,
F10 and F5).Leucopenia was induced in all groups by a single intraperitoneal injection of
carboplatin. Male papaya leaf juice was given to prevent leucopenia to groups M10 and M5 and
female papaya leaf juice was given to F10 and F5. On days O, 7, 14 and 21 blood samples were
collected by cardiac puncture for white blood cell count. Significance of different was calculated
by one way ANOVA.
Results: After carboplatin injection, white blood cell count decreased. Papaya leaf juice
prevented fall in white blood cell count throughout the study period with p-value < 0.001. White
blood cell counts were significantly high in all groups as compared to control on day 7 with no
significant difference between gender and dose.
Conclusion: Papaya leaf juice prevents leucoopenia induced by carboplatin in a dose
dependent manner. There is no difference between male and female plants in this respect