Correlation Between Transglutaminase Antibody (TGA) Ratio and Histological Findings of Villous Atrophy in Celiac Disease By Marsh Grading

Abstract

Objective: To assess the correlation between TGA ratio and degree of duodenal damage by
using histologic Marsh grading in patients with CD.
Methods: This present study was conducted in the Department of Histopathology, Shaikh
Zayed hospital, Lahore. After taking informed consent (from the patients and guardians in case of
minors), endoscopic biopsy from the distal duodenum was taken routinely. Data was
computerized with window SPSS version 22. P value ≤ 0.05 was considered significant.
Results: In our study, the mean age of the patients was 32.23±16.37 years and male to female
ratio was 1.08:1. The mean TGA ratio of the patients was 16.51±7.37. A strongly positive
correlation was found between the Marsh grading of CD and TGA ratio of the patients i.e. r=0.872.
Statistically, a highly significant difference was found between Marsh grading and TGA ratio.i.e. p-
value=0.006
Conclusion: The results of our study concluded that the titer of TGA ratio is strongly correlated
with duodenal histologic Marsh grading in patients of CD.