Insulin Resistance and Beta-cell Function in Adolescent Hypertensive Patients

Abstract

Objective: To find out the role of insulin resistance and beta cell function in developing
hypertension in adolescent hypertensive patients.

Methods: Study included 50 students of Shalamar Medical and Dental College, age range 17-
19 years with family history of hypertension. 50 age matched subjects with no history of any
disease were taken as controls. Duration of study was Dec 2016 to June 2017. Demographics of
patients were entered in Proforma. Level of blood glucose was estimated by glucose oxidase
method. Level of serum insulin was estimated by ELISA. Values of insulin resistance and function
of beta cell were calculated using formula.

Results: Mean age of both subjects and control was 19 years with increased BMI and sedentary
life style belonging to middle and high socioeconomic status. Both systolic and diastolic blood
pressure in subjects with positive family history was non-significantly high in comparison with
controls. Fasting blood sugar and insulin resistance was increased in tested subjects, but
significant difference was only observed in case of insulin resistance in comparison with controls.
Beta cell function was significantly decreased in subject with family history of hypertension in
comparison with controls.