Association of Leucocytosis And Development of Early Left Ventricular Systolic Dysfunction in Patients With Acute Myocardial Infarction

Abstract

Objective: To assess the association between leucocytosis and development of early left
ventricular systolic dysfunction in patients presenting with first episode of acute myocardial
infarction.
Methods: 100 patients presenting with AMI were included in this case control study, conducted
at Coronary Care Unit of Services Hospital Lahore from March, 2015 to September, 2015. Blood
samples obtained in the first 24 hours after the onset of pain were analyzed for cardiac enzyme
levels and cell count. Echocardiography was performed on days 3-5. Patients with LVEF < 40%
were assigned to the left ventricular systolic dysfunction group (n = 50) and those with LVEF ≥
60% were taken as controls (n = 50).
Results: The mean age in the sampled population was 57.36 ± 7.344 years. 22(44%) of the
patients who developed LVSD had Leucocytosis, while only 07 (14%) patients in the control group
had leucocytosis. The association between leucocytosis and LVSD in patients with AMI was
statistically significant (Odds ratio = 4.827 95% CI 1.821 12.791, p = 0.001). There was no effect
of gender, diabetes mellitus, hypertension and Hyperlipidemia on the association.
Conclusions: It is concluded that there is a strong association between Leucocytosis and
development of early LVSD in patients presenting with AMI.