Comparison of Mean Blood Loss in Females Undergoing Normal Vaginal Delivery at Term with and without Tranexamic Acid

Abstract

Objective: To compare mean blood loss in females undergoing normal vaginal delivery at term
with and without tranexamic acid.
Methods: This randomized controlled trial was conducted in the department of Obstetrics and
Gynecology, Unit-3, Jinnah Hospital, Lahore over a period of six months from 15-01-2015 to 14-
07-2015. Two hundred patients (100 in each group) were included in this study. In group-A,
patients were given 1gm of Tranexamic acid intravenous while in group-P (placebo) patients
received 10ml of normal saline. Vaginal bleeding was examined immediately after the delivery of
placenta and up to 2 hours of delivery. pre weighed pads were used to collect spilled blood and
weighed again to calculate blood loss. The collected data was analyzed by using SPSS version
17.0. Quantitative variables like age, gestational age and blood loss was presented in form of
mean ± SD. Both groups were compared for mean blood loss using t-test taking p value < 0.05 as
significant.
Results: Patients were ranged between 18 to 30 years. Mean age of the patients was
23.49±3.27 and 24.09±3.67 years in group-A and P respectively. Mean gestational age was
38.98±1.25 weeks in group - Aand 39.00±1.42 weeks in group-P (Table-2). Mean BMI in group-A
was observed 21.96± 1.63 kg/m2 and in group p 21.49±1.64 kg/m2. Mean blood loss in group - A
was 251.22±50.30 ml and group-P was 363.25±70.70 ml. Statistically significant difference
between two groups was seen (p<0.001).
Conclusions: Tranexamic acid is effective in preventing PPH when compared with placebo