Protective Effects of Flaxseeds (Linum Usitatissimum L.) on Hepatotoxicity Induced by Triazophos on Male Wistar Rats

Abstract

Objective:To determine the effects of flaxseeds on triazophos-induced-hepatotoxicity.
Methods: In the current study 24 Wistar albino rats (age: 6-8 weeks, weight 150-200gms) were
segregated into four groups comprising six rats each. Group Awas kept as control group. Groups
B, C and D were labelled as experimentalgroups. Group B was given powdered flaxseeds
(800mg/kg b.w.), Group C was administeredtriazophos (8.2mg/kg b.w.) and Group D was
giventriazophos (8.2mg/kg b.w.) and flaxseeds (800mg/kg b.w.), each dose was administered
twice in a day for 21 consecutive days.On day 22, 24 hours after administration of last dose, all the
rats were sacrificed under deep anesthesia. Liver slides were made for H & Estaining. Number of
degenerated hepatocytes and nuclear pyknosis were observed in each group.
Results:Number of degenerated hepatocytes and pyknotic nuclei were alleviated in group D
with the simultaneous use of flaxseeds. (Pvalue ≤ 0.005).
Conclusions: Flaxseeds in powdered form decreases hepatotoxicity induced by triazophos.