Comparison of Chondroprotective Efficacy of Hyaluronic Acid and Piroxicam in Murine Model of Osteoarthritis

Abstract

Objective: To evaluate and compare the chondroprotective efficacy of hyaluronic acid and piroxicam in
murine model of osteoarthritis.
Method: Study was carried out at Pharmacology Department, Army Medical College (AMC), Rawalpindi.
Duration of this study was from May to July 2019 Osteoarthritis was induced by medial meniscus and anterior
cruciate ligament resection of right knee joints in twenty-four rats. They were divided in three groups. Group
A, B and C were treated with intra articular saline, hyaluronic acid and piroxicam once weekly for four weeks
respectively and then gait pattern was scored. Animals were sacrificed thereafter and samples were collected
for histopathology.
Results: Comparison of gait score of A, B and C groups exhibited a p value of <0.01. while, comparison of
gait of group A and B, group A and C and group B and C depicted p value of <0.001, <0.001and 0.771 respectively.
Likewise, collective histopathological analysis of control, piroxicam and triamcinolone groups showed p value
of <0.01. While Intergroup histopathological comparison of group A and B, group A and C and group B and C
showed p value of <0.001, <0.001 and 0.239 respectively.
Conclusion: Intra articular administration of hyaluronic acid and piroxicam exhibited parallel chondroprotective
efficacy in murine models.

How to cite: Ishaq N, Saqib M, Salahuddin Z, Gul S, Ata N, Rahman Z. Comparison of Chondroprotective Efficacy of Hyaluronic
Acid and Piroxicam in Murine Model of Osteoarthritis. Esculapio - JSIMS 2022;18(03):282-286