Effect of Cinnamomum cassia Bark Extract, Pyridoxine and Pitavastatin on Diet-Induced Murine Hypertriglyceridemia and Obesity

Abstract

Objective: To compare effects of aqueous Cinnamomum cassia bark extract (ACCE), pyridoxine (PYR) and pitavastatin (PIT) and dietary prevention on TG and body weight of rats.
Methods: Sixty albino male rats: sorted into 10 groups (Group 1 - control). Group 2 (dietary preventive) and Groups 3-10 (therapeutic) were induced using HFD for 30 days (HFD continued throughout). Group 2 was later reverted to normal diet. They were treated post-induction for 30 days, once daily: Group 3 (PIT 0.3mg/kg); Group 4 (PYR 18mg/kg), Group 5 (ACCE 200mg/kg), Group 6 (PIT 0.3mg/kg + PYR 18mg/kg), Group 7 (PYR 18mg/kg + ACCE 200mg/kg), Group 8 (PIT 0.3mg/kg + ACCE 200mg/kg), Group 9 (PIT 0.3mg/kg + PYR 18mg/kg + ACCE 200mg/kg) and Group 10 (PIT 0.15mg/kg + PYR 9mg/kg + ACCE 100mg/kg). TG and weight was checked (Day 0, Day 30, Day 60) and data analyzed using SPSS 20.0 (P ≤ 0.05).
Results: Rats showed significant reduction in serum TG after treatment. Maximum effect was seen in Group 7 (PYR 18mg/kg + ACCE 200mg/kg) where TG levels decreased to 94.667 ± 20.077 mg/dL. Dietary alteration in Group 2 resulted in only marginal improvement. Weight reduction of 23 gm was seen in Group 4 (ACCE 200mg/kg).
Conclusions: Cinnamon, pyridoxine and pitavastatin showed remarkable TG-lowering activity. PYR and ACCE exhibited additive effect (39%), endorsing the need for “integrated” approach.
Cinnamon can treat obesity in humans.