Consequences of Different Solid Malignancies in Stage I and II on The Level of Antithrombin III A Natural Anticoagulant

Abstract

Objective: To elaborate the association between the levels of natural anticoagulant antithrombin III (AT) in already diagnosed cases of different solid malignancies at stage I or II.
Methods: A cross sectional study was carried out in the Department of Pathology, Lahore General Hospital and Sheikh Zaid Hospital Lahore. Diagnosed cases of solid malignancies were selected from INMOL Hospital Lahore. 52 subjects of already diagnosed cases of solid malignancies were selected according to the selection criteria. They were divided in 2 groups, group 1 encompassed 26 subjects of stage I solid malignancy, while group 2 comprised of subjects who were diagnosed as stage II solid malignancy. Automated Coagulometer Sysmex CA 600 was used to measure AT levels and the subsequent data was recorded. Data was statistically analyzed using SPSS 20.
Results: The mean AT level in group I was 128.1±16.4 and in group II was 111.6±12 respectively. Results reveal that there was significant difference in mean AT level between the two groups (p value < 0.001).
Conclusions: It was concluded that the AT level is decreased in solid malignancies even in initial stages. Mean AT in subjects of group II was significantly lower (p value <0.001) as compared to subjects of group I. So, as the stage of malignancy advances AT level decreases and number of AT deficient subjects increases