Association of H pylori and Morphological Changes in Mucosa of Esophagus and Gastric Antrum in Patients with Dyspepsia.

Abstract

Objective: To find association between H pylori and morphological changes in mucosa of
oesophagus and gastric antrum in Patients having dyspepsia.
Methods: One hundred sixty nine patients presenting to outpatient department of Medical units
of Lahore General Hospital and services hospital Lahore with symptoms of dyspepsia were
included in the study. This study was conducted at Pathology Department of Post Graduate
Medical Institute. Endoscopy of all included patients was done in the medical unit, services
hospital and endoscopic biopsies from distal esophagus and gastric antrum were taken
simultaneously.
Results: Out of 169 patients 31 were H. Pylori positive, 30 (96.8%) cases were with chronic
inflammation, 22 (70.9%) cases with neutrophil infiltration, 21 (67.7%) case atrophic changes, 4
(12.9%) cases with metaplasia/dysplasia and 01 (3.2%) case was with malignancy.
Conclusions: Dyspeptic patients with H. pylori infection in esophageal mucosa are prone to
develop morphological changes, however, histopathological changes in oesophageal and gastric
mucosa of such patients are present in both H. Pylori positive and negative subjects but more in
H. Pylori negative cases.