Frequency Of Type 2 Diabetes Mellitus And Comparison Of The Mean Alt And Ast Levels Between The Type 2 Diabetic And Non-diabetic Patients

Abstract

Objective: To determine the frequency of Type 2 diabetes mellitus and comparison of the mean
ALT and AST levels between Type 2 diabetic patients and non-diabetic patients.
Methods: The study was conducted in Department of Medicine, Services Hospital Lahore.
Randomly 300 patients were enrolled from outpatient department of medicine. Sample size of
300 cases was calculated with 95% confidence level and 3% margin of error taking expected
frequency of diabetics to be 7.6% 2. Patients were selected with Non probability, consecutive
sampling technique. Patients were invesigated by performing Fasting blood glucose level, oral
glucose tolerance test and Glycated HemoglobinA1c (HbA1c) level and diagnosed as diabetics
as per American diabetic association criteria4. Newly diagnosed diabetics were segregated as
type 1 and type 2 on the basis of clinical criteria4 i.e. age of onset, body mass index (BMI), insulin
requirement as initial therapy, previous history of diabetic ketoacidosis and associated
autoimmune disorders.
Results: Frequency distribution of patients with Type 2 diabetes mellitus showed that among
300 patients, 19%(n=57) had Type 2 diabetes mellitus . Mean ALT levels were deranged more in
Type 2 diabetics (38.2±13.4) as compared to non diabetic patients (29.7±12.6). Mean AST levels
were were also deranged more in Type 2 diabetics (39.7±12.7) as compared to non diabetics
(32.6±14.1).
Conclusions:Mean AST and ALT values in patients with type 2 diabetes mellitus were
deranged more than that of non diabetic patients.