Determination of Age of Puberty Using Leptin Level in Male Popualtion

Abstract

Objective: Innovating puberty analysis via utilization of leptin as a biomarker to revolutionize
existent archetype prototype paragon
Methods: It was a cross sectional study based on pubescence markers utilized as landmark
criterion. Healthy volunteer males of disparate maturescens were selected. Their physical
maturity was substantiated via gold standard tanner staging and correlative algorithm was
established with serum leptin levels. Sample size calculative of 150 was collected.
Results: Leptin levels dependent on age groups were stratified. These leptin level ranged from a
minimum pre-pubertal level of 0.174 ng/ml to maximum 7.704 ng/ml at puberty initiation, which
exhibited a peak uprise of the leptin mean value of 3.57 ng/ml ± Std. Dev. 1.608 ng/ml, during the
puberty startup averaging up to 12.5 years, with a progressive decline from mid-puberty to post-
puberty age represented by the fall in leptin level from 2.539 ng/ml to 0.174 ng/ml respectively,
with a mean value of 1.021 ng/ml ± 0.611 ng/ml
Conclusions: Leptin incentivized study was in pursuance of establishing a correlation between
leptin in regards with juvenility along with evaluating range of leptin levels at which the maturity is
initiated. The prospective study was deployed via utilizing pinnacle paradigm of tanner staging
supplemented by leptin analysis. Data obtained was analyzed statistically for computation of
puberty attainment age. Epitome of research conclusively analyzed a correlation between serum
leptin and puberty initiation and an incontrovertible definitive leptin level range to assess the
maturescence staging from initiation to complete adulthood.