Microscopic Anatomy of Aging Human Prostate Histological Architecture of BPH

Abstract

Objective: To study the histological architecture of aging human prostate.
Methods: To study the histological architecture of aging human prostate. Materials and
methods: Twenty samples of chips of human prostate (transitional zone) were collected from
patients of benign prostatic hypertrophy (BPH), by transurethral resection of prostate (TURP)
performed at Urology Department of Mayo Hospital Lahore. The parenchyma and stroma of the
transitional zones of aging prostate specimens were analyzed qualitative & quantitative.
Results: Luminal dimensions of acini in transitional zone of aging prostate were significantly
increased and height of the secretory epithelial cells (EH) was significantly reduced & they
became cuboidal to flattened. Both inter-acinar smooth muscle (SM) and collagen fibers (CF)
were increased between widely apart acini in BPH.a
Conclusions: The considerable increase in the luminal dimensions of the acini and significant
reduction in the height of epithelial cells of acini along with remarkable increase in both inter-
acinar muscle and collagen fibers are the hallmarks of BPH, and it signifies that both stromal and
glandular elements were involved in BPH