Correlation Between Mean Platelet Volume And Severity of Acute Diarrhea in Children

Abstract

Objective: To determine the correlation between mean platelet volume and severity of acute
diarrhea in children.
Methods: This cross-sectional study was conducted in Department of Pediatrics, King Edward
Medical University/ Mayo hospital Lahore in six months (January to June 2018). Total 100
patients aged between 2-60 months were enrolled. After obtaining demographic and clinical data,
severity of acute diarrhea was assessed by Modified Vesikari scoring system. Samples of
complete blood count were taken to calculate mean platelet volume. Data was analyzed using
SPSS 22. Pearson's correlation analysis was performed to estimate coefficient of correlation
between mean platelet volume and severity of diarrhea.
Results: A total of 100 patients of acute diarrhea were enrolled. The mean age of the patients
was 16±15 months. Out of 100, 57% were male and 73% patients were of age 2-24 months. The
mean MPV and severity score was 8.5±2.5 fL and 11.4±2.5 respectively. There was a negative
correlation between MPV and severity score with a Pearson correlation coefficient of -0.097 with
p-value 0.337. The correlation coefficient between MPV and severity score was -0.080 (p=0.553)
in males and -0.090 (p=0.566) in females. The correlation coefficient between MPV and severity
score was -0.152 (p=0.201) and 0.065 (p=0.747) in patients aged 2-24, and 24-60 month.
Conclusions: There is negative correlation between mean platelet volume and severity of
acute diarrhea. MPV may not be the determinant of severity of acute diarrhea.