Protective Effect of Malus Domestica (apple) Peel Extract on Carboplatin Induced Fall in Blood Platelet Count and Bone Marrow Megakaryocyte Percentage in Mice

Abstract

Objective: To evaluate the protective effect of Malus domestica (apple) peel extract on
carboplatin induced fall in blood platelet count in mice and also fall in bone marrow
megakaryocyte percentage in mice.
Methods: Forty adult male mice were divided into 5 groups. Group A was negative control and
only distilled water was given to mice. Group B was disease control and mice in this group
received carboplatin intraperitoneally in a dose of 125 mg/kg. Group C, D & E were experimental
groups and carboplatin along with the apple peel extract in three different doses of 25, 50 & 75
mg/kg was given. After 7 days, blood & tissue sampling was done.
Results: The results revealed that apple peel extract significantly prevented the fall in platelet
count and megakaryocyte percentage in all experimental groups treated with carboplatin.
Conclusions: Apple Peel Extract effectively prevented carboplatin induced fall in platelet count
and megakaryocyte percentage and produced m,ore significant results in a dose of 50 mg/kg.