Association of Liver Enzymes in the preeclampsia Patients Presenting In A Tertiary Care Hospital: Case Control Study

Abstract

Objective: To assess the association of preeclampsia with deranged liver enzymes of patients
presenting in a tertiary care hospital.
Methods: It was case a control study including 100 females who fulfilled the inclusion criteria.
They were enrolled in the study from OPD of Department of Obstetrics and Gynecology, Ghurki
Trust Teaching Hospital, Lahore. Informed consent was obtained. Then two groups were formed
i.e. cases with preeclampsia and controls without preeclampsia. Then blood sample was
obtained in 3cc BD syringe. All samples were sent to the laboratory of the hospital for assessment
of ALT and AST. Data was entered and analyzed by SPSS version 21.0. Odds ratio was calculated
to find association between preeclampsia and deranged ALT and AST.
Results: The mean age of the patients was 33.30 (±4.45) years in cases and 32.96 (±4.72) in the
control group. Mean gestational age was 33.88 (±4.07) weeks while 33.6 (±4.29) weeks in the
control group. It was observed that body mass index was 28.90 (±2.32) in cases and 31.45
(±3.76). Parity was also almost similar in the both groups. It was observed that among cases 14
(28%) of the participants had deranged. ALT and AST value while 3 (6%) in the control group
which was significant with Odds ratio >1.
Conclusions: Significantly deranged liver enzymes were observed in the eclampsia patients.
There is a need to conduct further study to know its relationship with disease.