Morphological Pattern of Endometrial Biopsy in Women with Clinical Diagnosis of Abnormal Uterine Bleeding

Abstract

Objectives: This study was carried out to determine the underlying gynecological pathology with help of morphological pattern of the endometrial histology in women of different age groups with clinical diagnosis of abnormal uterine bleeding.
Methods: This is a retrospective study of a series of one hundred and twenty cases of women with presenting complaint of abnormal uterine bleeding. This study was done in the Department of Pathology, Rashid Latif Medical College, in collaboration with Gynecology departments of Arif Memorial Hospital and Hameed Latif Hospital over period of one year. (July 2018 to June 2019). One hundred and twenty cases of endometrial curettage, with clinical impression of abnormal uterine bleeding were analyzed and reported by two histopathologists. Patients with complications of pregnancy were excluded from present study.
Results: Histopathological examination of endometrial curetting revealed spectrum of morphology from physiological changes to malignancy. Endometrium with normal cyclical changes were seen in 64 (53.33%) cases, followed by endometrial polyp 18 (15%) cases, endometrial hyperplasia 15 (12.5%), and disordered proliferative of endometrium 10 (8.33%) cases. Malignancy was noticed in 3 (2.5%) cases. Malignancy was diagnosed mostly in the postmenopausal age group.Conclusion: The present study proves that on routine basis endometrial histopathological evaluation is a useful diagnostic measure to determine the underlying cause of abnormal uterine bleeding which ultimately help in accurate treatment.