Pancreatic lipase and Pancreatic Amylase in Children with Type 1 Diabetes Mellitus

Abstract

Objective: To find out the serum levels of pancreatic lipase and pancreatic amylase in children with type 1 diabetes mellitus and to compare them with normal healthy children.
Methods: We conducted this cross-sectional comparative study at The Post Graduate Medical Institute, Lahore and The Children's Hospital and Institute of Child Health, Lahore from March 2018 – May 2019. We recruited 76 children ≤ 16 years of age with type 1 diabetes mellitus and 76 age and gender matched normal self-reported healthy children were recruited as control group. Children with recent history of mumps or any other recent comorbidity were excluded from study. After written informed consent, a detailed questionnaire regarding demographic data was recorded. Levels of pancreatic lipase and pancreatic amylase were estimated and noted. Data was analyzed using SPSS version 20.
Results: Pancreatic lipase and pancreatic amylase were significantly decreased in children with type 1 diabetes mellitus as compared to normal healthy controls. Furthermore, in children with type 1 diabetes mellitus pancreatic amylase was significantly negatively correlated with duration of the disease though this correlation was statistically non-significant.
Conclusion: Pancreatic lipase and pancreatic amylase were significantly decreased in children with type 1 diabetes mellitus as compared to normal healthy controls. In children with type 1 diabetes mellitus a nonsignificant negative correlation was observed in levels of pancreatic lipase and amylase with duration of the diabetes mellitus giving a clue towards progressive atrophic changes of exocrine pancreas along with underlying endocrine pathology.