Role of Fetuin-A and Fasting Blood Glucose in Predicting Pre-diabetes in First Degree Male Adolescents of Diabetic People

Abstract

Objectives: To evaluate the role of high levels of Fetuin-A and fasting blood Glucose in predicting prediabetes in first degree adolescents of diabetic people.
Methods: A cross sectional study was conducted in department of Biochemistry and Department of Pathology from January 2019 to December 2019 at Department of Biochemistry, Services Institute of Medical Sciences, Lahore. This study was carried on 35males first degree relatives (FDR)of diabetics and 35 male adolescents with no familial diabetic element. The age range of both groups was 18-30 years. Blood samples for estimation of blood glucose, serum insulin and Fetuin A of all subjects were collected in fasting condition. Insulin resistance was calculated by formulation.
Results: Mean age of adolescents was 19 years with a BMI 24.09. Majority of the first degree relatives of diabetics have sedentary life style using mixed diet along with junk food. Levels of fasting blood sugar, serum insulin, serum Fetuin-Aand insulin resistance were increased in male adolescents of diabetics as compared to adolescents of non-diabetics. Significant direct correlation of blood sugar with serum Fetuin-A and weak direct correlation with insulin resistance was observed in first degree relatives of diabetics.
Conclusion: Higher prevalence of impaired Fetuin-Aand fasting blood glucose was observed in first degree relatives of diabetics. Significant correlation between fasting blood glucose and serum Fetuin-Asuggests the role of Fetuin-Aas an early predictor of pre-diabetes in adolescents of diabetics.