Effect of Cassia Fistula Bark Hexane Extract on Lipid Parameters in Male Diabetic Rats

Abstract

Objective: To evaluate and compare the effects of Cassia fistula bark on serum lipids in high fat diet and streptozotocin instigated diabetic albino rats.
Method: Randomized controlled trial (RCT) carried out in Physiology department of Services Institute of Medical Sciences, Lahore from August 2017 to April 2018. Ninety male albino rats were randomly divided into two equal groups (n=45). Firstly, rats in both groups were fed on high fat diet. Secondly streptozotocin was injected to induce type 2 diabetes. The diabetic control group was designated as group-1 and kept on normal saline only. The Diabetic experimental group was fed on Cassia fistula bark (0.45g/kg body weight once a day) respectively for 30 days. Subsequently, blood samples (4-5ml intracardiac) were collected from each group member on the 31st day to evaluate the biochemical parameters of serum lipids.
Results: The hexane-based extracts of Cassia fistula lead to highly significant (p˂0.001) reduction in lipid profile of group-2.
Conclusion: Cassia fistula bark can significantly lower serum lipid parameters.