Immunohistochemical Expression of Clustered Differentiation 10 (CD10) Across Various Grade & Stage of Urinary BladderCarcinoma
DOI:
https://doi.org/10.51273/esc23.2519219Keywords:
Urothelial carcinoma, Clustered Differentiation 10(CD10), ImmunohistochemistryAbstract
Objective: To assess the Clustered Differentiation 10 (CD10) expression in Urothelial carcinoma and to
ascertain how its expression relates to grade and stage.
Method: Descriptive cross sectional research was carried out over a period of six months in Pathology Department on eighty five cases of bladder carcinoma from transurethral resection of bladder (TURBT) specimens diagnosed on Hematoxylin-eosin (H & E) stained sections irrespective of patient's age and gender were included in the study. These were stained for CD10 by Immunohistochemical technique.
Results: Sixty seven (78.8%) urothelial carcinomas showed positive CD10 staining while 18 cases (21.17%)
demonstrated negative expression. In 67 positive cases, 42 high grade tumors had 2+ expression while 13
grade had 1+ staining .All low-grade tumors(12) displayed 1+ score. Sixteen tumorsin pT1, 21 tumorsin pT2
and 3 tumors in pT3 stage displayed 2+ score. Nineteen tumors in pT1 while 4 tumors in pT2 had 1+ score.
Conclusion: Our findings indicate that CD10 expression is greater in high grade and invasive urothelial
carcinomas and is associated with progression of bladder carcinomas.
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