Immune Response of Hemodialysis Patients to Hepatitis B Vaccination

Abstract

Objective: To determine the immune response of hemodialysis patients to hepatitis B vaccination at Shaikh  Zayed Hospital, Lahore.
Method: It was a cross-sectional descriptive study done at the Microbiology Department of Shaikh Zayed  Hospital, Lahore after approval from the Institutional Review Board. Two hundred hepatitis B surface  antigen (HBsAg) negative patients were enrolled by convenient sampling technique. Their serum samples  were taken and hepatitis B surface antibody (anti-HBs) and hepatitis B core antibody (anti-HBc) were done by enzyme-linked immunosorbent assay (ELISA) technique. The data entry and analysis were done using the Statistical Package for Social Sciences (SPSS) version 25.
Results: The majority of the patients (96.5%) were vaccinated. The anti-HBs antibody was positive in 141(70.5%) patients. Out of 141(70.5%) anti-HBs positive patients, 62.5% patients had antibody titer between 10-100 IU/ml whereas only 8% patients had antibody titer of greater than 100 IU/L.
Conclusion: The anti-HBs levels were protective in 70.5% of the hemodialysis patients. The majority of the patients (62.5%) had antibody titer ranging between 10-100 IU/L and only 8% of the patients had antibody titer greater than 100 IU/L. Forty percent of patients were isolated anti-HBs positive whereas, in 30.5% of patients, both anti-HBs and anti-HBc were positive.

How to cite: Aslam A, Izhar M, Khan FA, Qanber S, Satti KN, Aslam M. Immune Response of Hemodialysis Patients to Hepatitis B Vaccination. Esculapio - JSIMS 2021;18(02).