Anti-Thyroid Peroxidase Antibodies in Euthyroid Pregnant Females to Detect Thyroid Autoimmunity

Abstract

Objective: To show case the early appearance of anti-TPO antibodies, before the onset of thyroid hormone disruption.
Methods: It was a cross-sectional study in which 227 antenatal women who were euthyroid (normal free T4 and free T3 levels) were included and their Anti-TPO antibodies were analysed and recorded.
Results: The mean age of the pregnant females was 25.67 + 4.531 years and the mean gestational age was 25.18 + 9.214 weeks. Among 227 pregnant females, 97.8% had anti TPO antibodies levels in the 0-30IU/ml range while only 2.2% had >30IU/ml. The mean anti TPO level among pregnant females was 7.020 + 4.004IU/ml. There was significant association (p<0.05) between trimesters and anti TPO Ab level while insignificant association (p>0.05) of anti TPO Ab with gravidity, parity and abortion.
Conclusion: Study concluded that adding anti-TPO antibodies together with markers of thyroid function such as TSH, FT4 and FT3 is not cost effective in identifying pregnant females who might develop thyroid dysfunction and associated pregnancy loss, preterm birth. The prevalence of Anti TPO Ab in euthyroid pregnant females in our study was only 2.2%.

How to cite: Sadaqat A., Mumtaz., Shami N., Nazir U. Anti-Thyroid Peroxidase Antibodies in Euthyroid Pregnant Females to Detect Thyroid Autoimmunity. Esculapio 2021;17(02):