The Association Between Rheumatoid Arthritis and Serum Levels of Vitamin D
DOI:
https://doi.org/10.51273/esc23.25131931Keywords:
rheumatoid arthritis, Women,, Vitamin D deficiencyAbstract
Objective: To find out the status of vitamin D in patients with Rheumatoid Arthritis.
Material and Methods: This comparative study was conducted in Govt Kot Khawaja Saeed Teaching Hospital. Duration of study was from June 2017 to June 2018. A case control study was carried out on 60 patients with Rheumatoid arthritis (age range 25 to 60 years fulfils the criteria of 2010 Rheumatoid arthritis classification. Duration of study was from June 2017 to June 2018. Patients/controls were comprised as group A (30 patients with mild arthritis), group B (30 patients with moderate form of arthritis) and group C (20 age, sex matched healthy controls).
Results: Mean age of patients was 36.50 years. Majority of women were house wives with average health status with normal pulse rate and blood pressure. Clinical variables of patients showed the small joint involvement, swelling, tenderness with moderate to severity of disease. It is observed that the level of vitamin D was significantly low in group of patients presented with severe form of arthritis as compared to group of patient who has mild to moderate arthritis. Study also observed that both group of patient has significantly
low levels of vitamin D as compared to controls.
Conclusions: Vitamin D deficiency is observed in patients with rheumatoid arthritis, and may be linked to severity in RA. It is therefore a need of supplementation of Vitamin D for the pain relief in RApatients.
References
Alam, S.M., Kidwai, A.A., Jafri, S.R., Qureshi, B.M., Sami, A., Qureshi, H.H et al (2011). Epidemiology of Rheumatoid Arthritis in a tertiary care unit, Karachi, Pakistan JPMA 61(2):50
Bullock, J., Rizvi, S.A.A., Saleh, A.M., Ahmed, S.A., Do, D.P., Ansari, R.A et al.(2018). Rheumatoid Arthritis: A Brief Overview of the Treatment. Med PrincPract.27(6):501-507. doi:10.1159/000493390
Dargham, S.R., Zahirovic, S., Hammoudeh, M., et al (2018). Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients. PLoS One. 13(12):e0208240. doi:10.1371/journal.pone.0208240
Novella-Navarro, M., Plasencia-Rodríguez, C., Nuño, L., Balsa, A. (2021). Risk Factors for Developing Rheumatoid Arthritis in Patients With Undifferentiated Arthritis and Inflammatory Arthralgia. Front Med (Lausanne). 8:668898. doi:10.3389/fmed.2021.668898
Tanaka, Y.(2020). Rheumatoid arthritis. Inflamm Regener 2020; 40: 20. doi.org/10.1186/s41232-020-00133-8
van Riel, PL., Renskers, L.(2016). The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis. ClinExpRheumatol. 34(5 Suppl 101):S40-S44.
Meena, N., Singh Chawla, S.P., Garg, R., Batta, A., Kaur, S (2018).. Assessment of Vitamin D in Rheumatoid Arthritis and Its Correlation with Disease Activity. J Nat Sci Biol Med. 9(1):54-58. doi:10.4103/jnsbm.JNSBM_128_17
Cecchetti, S., Tatar, Z., Galan, P., Pereira, B., Lambert, C., Mouterde, G. et al (2016). Prevalence of vitamin D deficiency in rheumatoid arthritis and association with disease activity and cardiovascular risk factors: data from the COMEDRA study. ClinExpRheumatol. 34(6):984-990.
Chandrashekara, S., Patted, A. (2017). Role of vitamin D supplementation in improving disease activity in rheumatoid arthritis: an exploratory study. Int J Rheum Dis. 20(7):825–31.
Charoenngam, N., Holick, M.F.(2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 12(7):2097. doi:10.3390/nu12072097
Harrison, S.R., Jutley, G., Li, D. et al (2020).. Vitamin D and early rheumatoid arthritis. BMC Rheumatol 4:38. doi.org/10.1186/s41927-020-00134-7
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO et al.(2010). Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62(9):2569-81. doi: 10.1002/art.27584.
Nilsson, J., Andersson, M.L.E., Hafstrom, I., Svensson, B., Forslind, K., Ajeganova S. (2021) Influence of Age and Sex on Disease Course and Treatment in Rheumatoid Arthritis. Open Access Rheumatol. 2021;13:123-138 doi.org/10.2147/OARRR.S306378
Muhammad, A., Aslam, Z., and Umair, A. (2022). The Relationship Between Rheumatoid Arthritis and Serum Vitamin D Concentrations. P J M H S 16(05):1083-1085
Pawłowska, J., Smoleńska, Z., Daca, A., Witkowski, J.M., Bryl E.(2011). Older age of rheumatoid arthritis onset is associated with higher activation status of peripheral blood CD4(+) T cells and disease activity. ClinExpImmunol.163(2):157-164. doi:10.1111/j.1365-2249.2010.04294.x
van der Linden M.P., le Cessie, S., Raza, K., van der, Woude, D., Knevel, R., et al. (2010). Long-term impact of delay in assessment of patients with early arthritis. Arthritis Rheum. 62:3537–3546.
Moura, C.S., Abrahamowicz, M., Beauchamp, M., Lacaille, D., Wang, Y., Boire, G., et al. (2015). Early medication use in new-onset rheumatoid arthritis may delay joint replacement: results of a large population-based study. Arthritis Res. Ther. 17:197
Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N.J., Xu, J. (2018). Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res. 6:15. doi:10.1038/s41413-018-0016-9
Kostoglou-Athanassiou, I., Athanassiou, P., Lyraki, A., Raftakis, I., Antoniadis, C. (2012). Vitamin D and rheumatoid arthritis. TherAdvEndocrinolMetab. 3(6):181-187. doi:10.1177/2042018812471070
Hirani, V.(2012) Vitamin D status and pain: analysis from the Health Survey for England among English adults aged 65 years and over. Br J Nutr 107: 1080–1084
de la Torre L.P., Álvarez, M.M., Guzmán, M.C., Martínez, R.L. Acosta, C.R. (2020). Vitamin D is not useful as a biomarker for disease activity in rheumatoid arthritis. ReumatolClin.16(2):110–115 DOI: 10.1016/j.reumae.2018.02.014
Downloads
Published
How to Cite
Issue
Section
