Association of Various Subtypes of Renal Cell Carcinoma with Smoking, Grading and Staging

Abstract

Objective: To determine the association of various subtypes of Renal Cell Carcinoma with smoking, grading and staging.
Methods: A descriptive cross-sectional study was conducted in the Pathology and Oncology departments of King Edward medical University, Lahore from April 2019 to June 2020. A total of 226 cases were included in the study using purposive consecutive sampling. Association of tumor subtype with smoking, grade and stage of tumor was studied with the help of cross tabulation of these variables in SPSS 22.
Results: Out of the 226 cases, 57(25.2%) presented with high grade and 169(74.8%) with low grade RCC. Out of these, there were 98(43%) male smokers and 22(9.7%) female smokers. When subtype was cross-tabulated against smoking (p=0.013) there were 74(32.7%) cases of clear cell
carcinoma (including its subtypes sarcomatoid and rhabdosarcomatoid), 43(19.02%) cases of papillary RCC and 3(1.32%) cases of chromophobe RCC.
When subtype was cross-tabulated against stage (p=0.018), 62 (27.43%) cases of clear cell, 25(27.7%) cases of papillary and 3 (3.3%) cases of chromophobe variant presented at the T4 stage.
Conclusion: Chromophobe carcinoma of kidney is associated with smoking, higher grade and higher stage. We found no significant association of any other specific subtype with gender, smoking and grade of RCC.

How to cite: Bashir S., Virk R. A., Haider M.S., Mehmood F.M., Sarfraz R. Association of various subtypes of Renal Cell
Carcinoma with smoking, grading and staging. Esculapio 2021;17(02).