Protective effect of Aqueous Garlic Extract on Monosodium Glutamate Induced Toxicity on Johnson's Scoring of Infertility in Adult WistarRats

Abstract

Objective: To observe the effect of aqueous garlic extract (AGE) on the MSG-induced toxicity on the Johnson score of infertility in adult Wistar rats.
Method: This study was conducted at the University of Health Sciences, Lahore. A total of 24 adult male Wistar rats weighing 150-175 g and aged 6-8 weeks were collected and divided into 4 groups (6 rats each). Group Aacted as a control, with 6 ml / kg of distilled water given orally by gavage and intraperitoneally for 14 days. Group B received 4 g / kg MSG dissolved in 6 ml of distilled water intraperitoneally for 14 days. Group C orally administered 200mg / kgAGEdissolved in 0.4ml of distilledwaterfor 14 days by forced oral administration,and Group D first intraperitoneally administered 4 g / kg of MSG dissolved in 6ml of distilled water. Subsequently,
AGE 200 mg /kg dissolved in 0.4 ml of distilled water was given for 14 days by forced oral administration. All doses were administered once daily.
Results: At the end of study, one way ANOVAand Post hoc Tukey test were found to be significant (0.000) proving toxicity induced by MSG and protection rendered by AGE in B and D groups respectively.
Conclusion: Aqueous garlic extract improves and protects against the deleterious effects of MSG on Johnson'sScoring of infertility of adult Wistar rats.

How to cite:Ahmed HS, Inam F, Siddique A, Rauf F, Nasreen S, Fatima S. Protective effect of Aqueous Garlic Extract
on Monosodium Glutamate Induced Toxicity on Johnson's Scoring of Infertility in Adult Wistar Rats. Esculapio -
JSIMS 2022;18(04):248-252