HPV Infection and its Serotypes in Women with CIN and Cervical Cancer

Abstract

Objective: To analyze detection of HPV and its subtypes in patients with CIN and Cervical cancer in tertiary care hospitals in Lahore.
Material and Methods: It was descriptive, Cross sectional study conducted in Jinnah, Mian Munshi andINMOL Hospital, Lahore. The study was completed in a duration of 48 months. All patients presenting with symptoms associated with cervical pathology, abnormal cytology on pap smear and confirmed cases of cervical cancer on biopsy were included in this study. Cervical biopsies were taken both for histopathology and HPV testing in patients showing dyskariosis on cytology or visible cervical growth. Confirmed case of carcinoma cervix on biopsy had their sampling done for HPV testing.
Results: There were total 89(81.7%) positive samples for HPV. HPV 16 is the commonest serotype detected (31.3%). HPV 66 was the second commonest variant detected (13.1%). HPV 31, HPV 18, HPV 59 and HPV 45 were the other common serotypes.
Conclusion: Different HPV vaccines available in market provide immunity against 6,11,16,18,31,33,45,52 & 58. However these vaccines are not effective against HPV 66,59,32,61, and 86, which are quite prevalent in our population. So, vaccination and screening should go side by side in Pakistan to cover the disease caused by these non-vaccine type variants.
Keywords: Human papilloma virus, prevalence, distribution of HPV serotypes, invasive cervical cancer, risk factors.