Family History – An Indicator For Developing Type 2 Diabetes At Earlier Age

Abstract

Objective: Positive family history is an indicator for developing diabetes. Data are needed to determine if it effects age at onset of diabetes.
Method: This cross-sectional study was conducted at Ghurki Trust Teaching Hospital (GTTH) Lahore, in Diabetic And General Medical OPD. Enrollment for study began on January 1 2020, and ended on March 31 , 2020.We conducted a Cross-sectional study. 933 diabetics and 396 non diabetics were interviewed regarding family history and age at onset of diabetes. Patients were then categorized into three groups based on their familial risk as average, moderate and high.
Results: In the diabetic group 487 (52.2%) had an average familial risk of developing diabetes, while 299 (32%) and 147 (15.8%) had moderate and high familial risk respectively. Conversely, similar groups among the non-diabetic population had 312 (78.8%), 69 (17.4%) and 15 (3.8%) familial risk of developing diabetes. Relation of family history with the age at the time of diagnosis of diabetes was statistically significant (P<0.0001). In average risk diabetes group the average age at time of diagnosis of DM was found to be 43.9
years, whereas, with average, moderate and high familial risk the average age of the onset of diabetes was 46.04, 41.70 and 41.28 years, respectively. The individuals with a family history of diabetes are 2.83 times (95% CI: 2.19-3.65) more likely to get diabetes as compared to those with no family history of diabetes. Females were found to be 1.6 times more likely to have an early onset of diabetes and there are 1.88 times (95% CI: 1.18-2.99) more chances of having diabetes if the mother is diabetic (P<0.05).
Conclusions: Family history is a strong independent predictor of diabetes. Patients with moderate to high risk of diabetes develop diabetes at an earlier age. Diabetic mothers confers more risk of early development of diabetes than any other relative.

How to cite: Qureshi SS, Amer W, Zunair J, Beg BM. Family History – An Indicator For Developing Type 2 Diabetes At Earlier Age. Esculapio - JSIMS 2022;18(04):248-252..